There are a lot of unique match ups with Kassadin that play out very differently. It is important to know the basics on each one. I will list out the basics of the common match ups.
This is a skill match up. If you get knocked up you're probably going to die. He also has zoning potential due to his early damage and strong melee.
This match up isn't too hard. Her poke is annoying, but also not hard to avoid. At 6 she is very squishy and silence dominates her.
This match up is a lot more skill based than other match ups. Akali has a harder trade melee wise because of her Q proc, and both of you have multiple flashes. However, due to her being a melee, you get a relatively easy early game as kassadin, and make a bigger impact late game.
At level 6 you dominate Anivia. She is extremely squishy and silence cuts off all of her damage including her ultimate. However, I have a lot of trouble with her early game because of her huge base damage, as well as her CC and long Auto Attack range. Be very careful in lane.
Annie can absolutely crush you in lane phase. Her constant Spam of her Q can do work to you. Because of this, you need to constantly spam your null sphere and eventually make an out play. This is a hard match up pre 6.
Easy match up. Dodge his damage pre 6, dominate him after 6. Very basic match up.
This match up is like any other high harass mage. Try to avoid damage while farming pre 6, and at level 6 you can kill them with ease after some poke. Decently tough match up because of the high poke.
Cho'Gath does work to kassadin. He has a lot of poke because you are melee, and infinite sustain. He can also take down your tower rather quickly if you B or roam. I don't recommend picking Kassadin into a Cho'Gath mid, but if you have to go against him, its all on your farming abilities as well as quickly roaming and making a bigger impact than him.
A lot of people say Diana is a counter to kassadin mainly because she's some what tanky with strong melee and dashes. To be honest I don't mind the match up since her poke isn't too bad, and once you level up some after 6 you can easily duel her. Silence is op.
I heard having 8 abilities doesn't do much when you're silenced.
Annoying match up because of her constant poke in lane. Not too difficult.
At first it's annoying but once you get your abilities you can just silence his drain and free farm. You can also cancel his ultimate in team fights.
One of the hardest match ups for Kassadin for an AP champion. Early game he can constantly spam his abilities and deny you farm because of his strong melee poke. A good fizz will dominate kassadin until Kass gets items.
It's a free farm lane, and Kassadin can even kill him with Liandrys. This isn't a counter like you would think it would be. Galio also cant' take town towers too fast so you can roam freely.
I hate this match up.
Free farm lane because of the double melee lane. You have a higher impact of the game as Kassadin.
Heimer can constantly push you and harass you as well as take down your towers quickly. However if you farm up you can easily 1 combo him.
He has a very high kill potential on you all throughout the early game. Start armor, probably need seekers, and you NEED to avoid his Q-E knock up combo. This lane is hard but manageable.
Very, very difficult lane for kassadin early. Jayce is stupidly OP and has damage to kill you all throughout the early and mid game. However, once your 6 he is basically an ADC so you can combo him pretty hard and gain back lane dominance.
Karthus should never beat kassadin ever. Even pre 6 you can out damage him with your Q spam and avoiding his skittles. Extremely easy match up.
Another easy match up. Only thing she has on you is she doesn't run out of mana so be careful pre 6.
Pretty difficult match up but you out scale her as well as silence her so she cannot ult. Simply combo, bait the ult and walk away, and combo again.
He can kill you at all parts of the game if you're not carefully using your riftwalk. In lane he has high auto attack damage so I recommend using armor 5.
Armor 5 is needed to play vs Kha'zix. Pre 6 you can both out play each other but he has an advantage. After 6 this lane is easily Kassadins. Kha'zix is extremely squishy.
Your silence hits her first. You win.
Easy lane. Avoid poke early and smart cast your silence so she cant use her ultimate to stop it. You can also silence her escape. (her E) Don't get close to her unless you're going in for the kill.
Pretty easy lane just need to avoid getting rooted. Lux with barrier is nearly impossible to kill though.
Very annoying lane, but after 6 combo and walk away so that he can't get an ulti off on you. Continue to do it and you'll be fine.
Not that bad of a lane, avoid as much of harass as you can and silence the meditate.
This lane sucks, try to farm as best as you can and have a bigger impact mid and late game.
Avoid the root and the lane is easy. She has very bad poke.
Another easy lane unless she runs AD runes. If she uses AD runes you need armor or you'll easily get poked out.
Orianna can dominate you early game if shes good and you're not careful. After 6 even maxing shield and going heavy Magic resist she cant stop you from killing her.
One of the hardest match ups for Kassadin. You'll need jungle help. Lots of armor needed and don't try to trade you wont win. Just try to farm and survive.
Avoid his flame spitter when you're farming and you should be fine. You'll get denied a bit but not too badly since he pushes. Farming under tower is needed.
Ryze has kill potential on you early game because of his high burst and root. Silence him and he can't do anything.
People still play sion?
Hard match up because of the zoning potential and high early burst. If you get rooted you're going to die.
She will kill you if she hits 6 before you. Also heavy harass lane. Not an easy lane. But after 6 you can easily take her out.
Seekers armguard > talon
Surprisingly easy lane. Your passive MR helps with his magic damage, and your armor runes help with his AA damage. Hes squishy so you can trade with Q if you need to. Level 6 teemo dies.
I love this match up. You can out roam TF, and he can't really poke you down cause you can poke harder. As soon as he uses a card on a minion combo him.
This is possibly the absolute hardest match up in the game. With his AA poke, dot, and burst, he can easily zone you from minions, and also kill you.
Just land the silence and you easily beat him. Pre 6 it is easy too cause he is focused on farming.
He is annoying to go against. After 6 position smartly so he can't turn on you with his silence and stun.
Just avoid his poke as much as possible. He is a safe laner but your gap close makes his life difficult.
This is the hardest match up for Kassadin in the game.
Pretty annoying match up. His auto attack damage as well as his low cool down poke can be trouble. However even if you die to him you can come back after a few levels past 6.
Not as hard of a match up as you'd think. You can be really safe pre 6 and farm up. But after 6, bait his ultimate and just Riftwalk away. Then he is basically as squishy as an ADC and you can easily combo him if he doesn't go hexdrinker.
This lane is really hard. He can constantly harass you pre 6 and at 6 you need to bait his ultimate in order to finish him off.
She has high damage so don't get rooted or you will die.