This is the part of the game where Annie usually thrives.
Take mid lane, utilize
to last hit when you need to, and use it to harass with
when you don't.
When you get a
ready, try to actively zone your opponent by moving forward in the lane and using your autoattacks to last hit. If you are winning your lane already this can often force opponents away from last hit range because they will fear getting stunned.
It is important to try to soften your lane opponent before level 6 so you can burst them down if they are foolish enough to not recall.
Your standard 6 combo is
s they run.
It it very important to calculate your damage effectively when playing Annie, if they live with a tiny bit of hp you could've harassed them just a little bit more beforehand. Something to keep in mind.
If your opponent is too tanky to burst down, or is just too good at laning/evading you, consider ganking top or bottom. Annie is one of the best casters to do early game ganks like this since her level advantage will allow her to burst the duo laners easily and her stun helps net kills.
If you see your opponent leaving lane you should probably follow them, push your tower hard, or gank a different lane. As Annie, you need to control the early game, don't let your lane opponent run around ganking while you farm uselessly.
Good Annie laning matchups (1v1 caster):
Bad Annie laning matchups (1v1 caster):
(Will most likely outrange and dominate you, you must burst him down instantly to win)
(Has egg and can Q you if you try to approach)
(Superior range and does tons of damage, you must burst her before she can do the same to you)
(Hard to harass him since he just shurikens you every time you run to him and his burst at 6 is comparable to yours)
(LOlolol, no seriously, this bitch will ruin you, if you can stun her at 6 before she combos you, you may have a chance)
(Black Shield stops your stun)
(Counters most other mages early game 1v1, but falls off later)