I'd change your seals and glyphs.
Both hp/lvl and ap/lvl break even before or at lvl6 and karthus really isnt an earlygame champ to begin with.
By the time you can ult ap/lvl is already better.
And the same could be said for hp/lvl.
When facing an aggressive midgame champ it will take em at least some time to lower your hp.
Even if they start forcing you at lvl3, which is rather rare since you can annoy the hell out of em with Q to keep em somewhat at distance, the difference between flats and /lvl already shrunk down to ~20hp.
Thats hardly worth going flats for.
Especially since the negative will quickly turn into a positive.
Flat hp/ap on ranged mids are meh.
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Both hp/lvl and ap/lvl break even before or at lvl6 and karthus really isnt an earlygame champ to begin with.
By the time you can ult ap/lvl is already better.
And the same could be said for hp/lvl.
When facing an aggressive midgame champ it will take em at least some time to lower your hp.
Even if they start forcing you at lvl3, which is rather rare since you can annoy the hell out of em with Q to keep em somewhat at distance, the difference between flats and /lvl already shrunk down to ~20hp.
Thats hardly worth going flats for.
Especially since the negative will quickly turn into a positive.
Flat hp/ap on ranged mids are meh.